The next OCBE Biostatistics Seminar will be held on Thursday, February 1st, at 14:30-15:30 in Auditorium 13 (Domus Medica, Oslo).
Veronica Vinciotti, Associate Professor at the Department of Mathematics, University of Trento (Italy), will present about
Random graphical model of microbiome interactions in related environments
Abstract: The microbiome constitutes a complex microbial ecology of interacting components that regulates important pathways in the host. Measurements of microbial abundances are key to learning the intricate network of interactions amongst microbes. Microbial communities at various body sites tend to share some overall common structure, while also showing diversity related to the needs of the local environment. In this talk, I will describe a computational approach for the joint inference of microbiota systems from (count) metagenomic data for a number of body sites. The random graphical model (RGM) allows for heterogeneity across the different body sites via environment-specific copula graphical models, while quantifying their relatedness at the structural level via a joint generative model of the graphs. In addition, the model allows for the inclusion of external covariates at both the microbial and interaction levels, further adapting to the richness and complexity of microbiome data. In the last part of the talk, I will show how a similar methodology has been used to study cross-country cultural heterogeneity from (ordinal) survey data.
[Reference: V. Vinciotti, E. Wit, F. Richter. Random graphical model of microbiome interactions in related environments, 2023, https://arxiv.org/abs/2304.01956 ]
The OCBE biostatistics seminar series is organized by the Oslo Centre for Biostatistics and Epidemiology and is an arena for presenting new interesting work in biostatistics, both on the methodological and applied side, from researchers in Oslo, from Norway and abroad.
See also: https://www.med.uio.no/imb/english/research/centres/ocbe/events/biostat-seminar/ for updates or for subscribing to the events. If you'd like to be added in the "biostat-ext" mailing list, just let us know.
Other upcoming seminars this semester:
February 8th, 2024: Martin Bladt, University of Copenhagen, Denmark
Welcome!
Best wishes,
Valeria Vitelli
Associate Professor
Oslo Centre for Biostatistics and Epidemiology,
Department of Biostatistics, University of Oslo, Norway
mailto: valeria.vitelli@medisin.uio.no
webpage: http://www.med.uio.no/imb/english/people/aca/valeriv/
